Examples of Recent Projects

A young brown horse stands in a stall, facing the cameraExamples of Recent Projects

Norris JW, Watson JL, Tablin F, Kozikowski TA, Knych HK. Pharmacokinetics and competitive pharmacodynamics of ADP-induced platelet activation after oral administration of clopidogrel to horses. Am J Vet Res. 2019, 80(5): 505-512.

Cenani, A, Brosnan RJ, Knych, HK. In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid. Pharmacology. 2019, 103:10-16.

Reed R, Barletta M, Mitchell K, Hanafi A, Bullington A, Knych H, Quando J, Ryan C, Giguere S. The pharmacokinetics and pharmacodynamics of intravenous hydromorphone in horses. Vet Anaesth and Analg. 2019, 46(3): 395-404.

Balcomb CC, Heller MC, Chigerwe M, Knych HK, Meyer AM. Pharmacokinetics and efficacy of intravenous famotidine in adult cattle. J Vet Intern Med. 2018, 32:1283-1289.

Sadar MJ, Knych HK, Drazenovich TL, Paul-Murphy JR. Pharmacokinetics of buprenorphine after intravenous and oral transmucosal administration in guinea pigs (Cavia porcellus). Am J Vet Res. 2018 Mar;79(3):260-266.

Gleeson MD, Guzman DS, Knych HK, Kass PH, Drazenovich TL, Hawkins MG. Pharmacokinetics of a concentrated buprenorphine formulation in red-tailed hawks (Buteo jamaicensis). Am J Vet Res. 2018 Jan;79(1):13-20.

Guzman, DS, Houck, EL, Knych HKD, Beaufrere H, Paul-Murphy. Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus).Am J Vet Res. 2018 Dec; 79(12): 1239-1245.

Houck EL, Guzman DS, Beaufrere H, Knych HK, Paul-Murphey JR. Evaluation of the thermal antinociceptive effects and pharmacokinetics of hydromorphone hydrochloride after intramuscular administration to cockatiels (Nymphicus hollandicus). Am J Vet Res. 2018 Aug; 78 (8): 820-827.

Hector RC, Rezende ML, Mama KR, Steffey EP, Knych HK, Hess AM, Honkavaara JM, Raekallio MR, Vainio OM. Effects of constant rate infusions of dexmedetomidine or MK-467 on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg. 2017 Jul;44(4):755-765.

Guzman DS, Knych HK, Olsen GH, Paul-Murphy JR. Pharmacokinetics of a Sustained Release Formulation of Buprenorphine After Intramuscular and Subcutaneous Administration to American Kestrels ( Falco sparverius ). J Avian Med Surg. 2017 Jun;31(2):102-107.

Laniesse D, Smith DA, Knych HK, Mosley C, Guzman DS, Beaufrère H. In vitro characterization of a formulation of butorphanol tartrate in a poloxamer 407 base intended for use as a parenterally administered slow-release analgesic agent. Am J Vet Res. 2017 Jun;78(6):677-687.

Burton JH, Knych HK, Stanley SD, Rebhun RB. Potency and stability of compounded formulations of chlorambucil, melphalan and cyclophosphamide.  Vet Comp Oncol. 2017 Dec;15(4):1558-1563.

Waugh L, Knych H, Cole G, D'Agostino J. PHARMACOKINETIC EVALUATION OF A LONG-ACTING FENTANYL SOLUTION AFTER TRANSDERMAL ADMINISTRATION IN HELMETED GUINEAFOWL (NUMIDA MELEAGRIS).  J Zoo Wildl Med. 2016 Jun;47(2):468-73.

Sebbag L, Thomasy SM, Woodward AP, Knych HK, Maggs DJ. Pharmacokinetic modeling of penciclovir and BRL42359 in the plasma and tears of healthy cats to optimize dosage recommendations for oral administration of famciclovir. Am J Vet Res. 2016 Aug;77(8):833-45.

Cenani A, Brosnan RJ, Madigan S, Knych HK, Madigan JE. Pharmacokinetics and pharmacodynamics of intravenous romifidine and propranolol administered alone or in combination for equine sedation. Vet Anaesth Analg. 2017 Jan;44(1):86-97.

Burton JH, Stanley SD, Knych HK, Rodriguez CO, Skorupski KA, Rebhun RB. Frequency and Severity of Neutropenia Associated with Food and Drug AdministrationApproved and Compounded Formulations of Lomustine in Dogs with Cancer.. J Vet Intern Med. 2016 Jan-Feb;30(1):242-6.